主要组织相容性复合体I类抗原加工机制的进化与功能视角
Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery.
作者信息
Paulsson K M
机构信息
Rayne Institute, Centre for Molecular Medicine, Department of Medicine, University College of London, 5 University street, WC1E 6JJ, London, United Kingdom.
出版信息
Cell Mol Life Sci. 2004 Oct;61(19-20):2446-60. doi: 10.1007/s00018-004-4113-0.
Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.
主要组织相容性复合体（MHC）I类分子将抗原肽呈递给CD8+ T细胞，为免疫识别病原体感染细胞提供了基础。主要由胞质溶胶中的蛋白酶体产生的肽通过与抗原加工相关的转运体（TAP）转运到内质网腔中。MHC I类分子的成熟由许多辅助蛋白和伴侣蛋白控制，这些蛋白在不同程度上致力于MHC I类分子的组装。几种新鉴定的蛋白已被证明在这一过程中发挥重要作用。本综述重点关注抗原加工机制（APM）组分与MHC I类分子本身之间的功能关系和进化史。这些对于进一步阐明免疫系统的起源以及总体上理解抗原呈递和免疫学机制具有重要意义。
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