Lazar S, Soukri M, El Haddad M, Akssira M, Leger J M, Jarry C, Morin Ph, Guillaumet G
Laboratoire de Chimie Bioorganique et Analytique, Université Hassan II--Mohammédia, Morocco.
Chirality. 2005 Jan;17(1):30-6. doi: 10.1002/chir.20090.
A rapid and simple procedure for enantioselective preparation of 2- and 3-substituted 2,3-dihydro[1,4]dioxino[2,3-b]pyridine derivatives (A and B, respectively) is described. The enantiomeric purity of each isomer was determined by capillary electrophoresis using a dual-cyclodextrin system (S-beta-CD/beta-CD) dissolved in formic acid-ammonia buffer (pH 4, ionic strength 50 mM).
描述了一种对映选择性制备2-和3-取代的2,3-二氢[1,4]二氧杂环戊烯并[2,3 - b]吡啶衍生物（分别为A和B）的快速简便方法。使用溶解于甲酸 - 氨缓冲液（pH 4，离子强度50 mM）中的双环糊精系统（S-β-CD/β-CD）通过毛细管电泳测定每种异构体的对映体纯度。
