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高强度超声对红细胞膜的损伤

[Damage to erythrocyte membranes induced by high-intensity ultrasound].

作者信息

Adzerikho I E, Kozlova N M, Antonovich A N, Zubritskaia G P, Slobozhanina E I

出版信息

Biofizika. 2004 Sep-Oct;49(5):845-51.

PMID:15526470
Abstract

The effect of high-intensity ultrasound (11.2-54.2 W/cm2, frequency 36 kHz) on the structural and functional state of erythrocytes was investigated. It was shown that, at short-term action of the ultrasound (up to 1 min), the dose-dependent hemolysis of erythrocytes occurs. It was found that the exposure to ultrasound of high intensity (54.2 W/cm2) leads to the disruption of the structural state of erythrocyte membranes, which manifests itself in a change of microviscosity of the lipid bilayer of membranes and inhibition of the activity of the lipid-dependent membrane-bound enzyme acetylcholinesterase.

摘要

研究了高强度超声(11.2 - 54.2 W/cm²,频率36 kHz)对红细胞结构和功能状态的影响。结果表明,在超声短期作用(长达1分钟)下,红细胞会发生剂量依赖性溶血。研究发现,暴露于高强度超声(54.2 W/cm²)会导致红细胞膜结构状态的破坏,这表现为膜脂质双层微粘度的变化以及脂质依赖性膜结合酶乙酰胆碱酯酶活性的抑制。

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Biofizika. 2004 Sep-Oct;49(5):845-51.
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