Cucuianu M, Nistor T, Hâncu N, Orbai P, Muscurel Corina, Stoian Irina
University of Medicine and Pharmacy "Iuliu Haţieganu" Cluj-Napoca, 13 Emil Isac St., 3400 Cluj-Napoca, Romania.
Rom J Intern Med. 2002;40(1-4):43-51.
When compared with values recorded in 14 control subjects, the 15 overweight patients with type 2 diabetes displayed significantly increased activities of serum alanineaminotransferase (172% of mean values in controls), gamma-glutamyltransferase (253%) and cholinesterase (139%). A much wider dispersion of individual values for the two firstly mentioned enzymes was however noted so that their correlation with serum triglycerides levels were weaker (r = 0.373; p < 0.05 and r = 0.451; p < 0.05 respectively) than the same correlation obtained for serum cholinesterase (r = 0.760; p < 0.001). In two other studies including 28 controls and 30 diabetic patients serum cholinesterase was found to be significantly correlated with serum levels of insulin (r = 0.622; p < 0.001), C-peptide (r = 0.652; p < 0.001) and free fatty acid (r = 0.821; p < 0.001). Circumstantial evidence is provided that insulin resistance and an increased flux of free fatty acids from adipose tissue to the liver would stimulate the hepatic synthesis of serum cholinesterase.
与14名对照受试者记录的值相比，15名超重2型糖尿病患者的血清丙氨酸转氨酶（为对照平均值的172%）、γ-谷氨酰转移酶（253%）和胆碱酯酶（139%）活性显著增加。然而，注意到前两种酶的个体值离散度要大得多，因此它们与血清甘油三酯水平的相关性（分别为r = 0.373；p < 0.05和r = 0.451；p < 0.05）比血清胆碱酯酶的相同相关性（r = 0.760；p < 0.001）弱。在另外两项研究中，包括28名对照者和30名糖尿病患者，发现血清胆碱酯酶与血清胰岛素水平（r = 0.622；p < 0.001）、C肽（r = 0.652；p < 0.001）和游离脂肪酸（r = 0.821；p < 0.001）显著相关。有间接证据表明，胰岛素抵抗以及游离脂肪酸从脂肪组织到肝脏的通量增加会刺激肝脏合成血清胆碱酯酶。
