Gninafon M, Tawo L, Kassa F, Monteiro G P, Zellweger J P, Shang H, Lambregts K, Trébucq A
National Tuberculosis Programme, Cotonou, Benin.
Int J Tuberc Lung Dis. 2004 Oct;8(10):1242-7.
National Tuberculosis Programme (NTP), Cotonou, Benin.
To study the patient characteristics and outcome of tuberculosis retreatment cases in a well-functioning NTP.
A retrospective, register-based study of all smear-positive pulmonary tuberculosis cases put on retreatment (2SERHZ/1ERHZ/5R3H3E3) between 1992 and 2001 in Cotonou. For comparison, information on new smear-positive cases in Cotonou in 1999 was entered and analysed.
Of 8103 tuberculosis patients registered, 642 were put on retreatment. The analysis is mainly based on the 236 patients whose initial treatment regimen records were available (113 relapses, 84 failures, 39 returns after default). Most of the relapse (57%) and return after default (72%) cases were put on retreatment within 12 months after stopping their initial treatment. Overall, the retreatment results were satisfactory (78% success) and comparable with those of new cases (82%); the failure rates were low (3%), as were those for initial treatment (1%). There were more defaulters from retreatment among those who had already defaulted from initial treatment (21%). Treatment success rates were better among women than men.
The standardised retreatment regimen is effective in Cotonou, probably because the NTP is functioning well, there are no drug shortages, drug taking is strictly supervised, and a good treatment plan is followed.
贝宁科托努国家结核病规划（NTP）。
研究运作良好的国家结核病规划中结核病复治病例的患者特征及治疗结果。
对1992年至2001年间在科托努接受复治（2SERHZ/1ERHZ/5R3H3E3）的所有涂片阳性肺结核病例进行一项基于登记的回顾性研究。为作比较，录入并分析了1999年科托努新涂片阳性病例的信息。
在登记的8103例结核病患者中，642例接受复治。分析主要基于236例有初始治疗方案记录的患者（113例复发、84例治疗失败、39例中断治疗后返回）。大多数复发（57%）和中断治疗后返回（72%）的病例在停止初始治疗后的12个月内接受复治。总体而言，复治结果令人满意（成功率78%），与新病例的结果（82%）相当；失败率较低（3%），初始治疗失败率也较低（1%）。在初始治疗时就已中断治疗的患者中，复治中断治疗的情况更多（21%）。女性的治疗成功率高于男性。
标准化复治方案在科托努有效，可能是因为国家结核病规划运作良好，没有药物短缺，服药受到严格监督，并且遵循了良好的治疗方案。
