Ngo Peter, Furuta Glenn, Burks Wesley
Division of Pediatric Gastroenterology, Children's Hospital of Boston, 300 Longwood Avenue, Hunnewell, Ground Floor, Boston, MA 02115, USA.
Curr Gastroenterol Rep. 2004 Dec;6(6):436-40. doi: 10.1007/s11894-004-0064-8.
Over the past decade clinicians have witnessed a dramatic rise in the prevalence of eosinophilic gastrointestinal diseases. Diverse symptoms, a broad range of endoscopic findings, and varying histopathologic features pose several questions: Do eosinophils represent an allergic response? What mechanisms drive eosinophils to specific mucosal targets? How do eosinophils affect the gastrointestinal tissues? Recent clinical and basic studies are investigating the pathogenesis of eosinophilic gastrointestinal diseases. This review highlights the literature concerning the mechanisms that govern these diseases, with a specific focus on diseases of gastrointestinal columnar epithelia (eosinophilic gastroenteritis and eosinophilic colitis). The roles of specific chemokines, such as eotaxin, and the data supporting the involvement of eosinophil granule proteins in disease states, are discussed.
在过去十年中，临床医生目睹了嗜酸性粒细胞性胃肠疾病患病率的急剧上升。多样的症状、广泛的内镜检查结果和不同的组织病理学特征引发了几个问题：嗜酸性粒细胞是否代表一种过敏反应？哪些机制驱使嗜酸性粒细胞靶向特定的黏膜部位？嗜酸性粒细胞如何影响胃肠道组织？近期的临床和基础研究正在探究嗜酸性粒细胞性胃肠疾病的发病机制。本综述重点介绍了有关这些疾病发病机制的文献，特别关注胃肠道柱状上皮疾病（嗜酸性粒细胞性胃肠炎和嗜酸性粒细胞性结肠炎）。文中讨论了特定趋化因子（如嗜酸性粒细胞趋化因子）的作用以及支持嗜酸性粒细胞颗粒蛋白参与疾病状态的数据。
