Welborn Jeanna, Jenks Helen, Taplett Janet, Walling Paula
Department of Internal Medicine, University of California at Davis Medical Center, UCDMC Cancer Center, Room 3017, 4501 X Street, Sacramento, CA 95817, USA.
Cancer Genet Cytogenet. 2004 Nov;155(1):33-41. doi: 10.1016/j.cancergencyto.2004.03.001.
Neuroendocrine tumors represent a spectrum of tumor types with different biologic and clinical features. The morphologic types include the low-grade typical and atypical carcinoids and the high-grade small cell and large cell neuroendocrine carcinomas (NECs). Cytogenetic descriptions of high-grade NECs are rare. Complete karyotypic descriptions of 34 high-grade NECs are reviewed: 7 extrapulmonary small cell NECs, 3 metastatic NECs of unknown primary, and 24 small cell lung carcinomas (SCLCs). Chromosomal deletions are more frequent than gains and often involve the entire chromosome arm. Typical aberrations are deletions of chromosome 3p, 5q, 10q, and 17p and gains of 1q, 3q, and 5p occurring as isochromosomes. Non-small cell lung cancers (NSCLCs) have different cytogenetic aberrations, but those with a metastatic phenotype display the identical aberrations as SCLC, a tumor known for its metastatic phenotype at onset. A genetic classification of lung cancer that incorporates the pattern of recurrent chromosome aberrations may be a better predictor of clinical outcome than a morphologic classification.
神经内分泌肿瘤是一系列具有不同生物学和临床特征的肿瘤类型。形态学类型包括低级别典型类癌和非典型类癌以及高级别小细胞和大细胞神经内分泌癌（NEC）。关于高级别NEC的细胞遗传学描述很少。本文回顾了34例高级别NEC的完整核型描述：7例肺外小细胞NEC、3例原发灶不明的转移性NEC以及24例小细胞肺癌（SCLC）。染色体缺失比获得更常见，且常累及整个染色体臂。典型的畸变是3p、5q、10q和17p染色体的缺失以及作为等臂染色体出现的1q、3q和5p染色体的获得。非小细胞肺癌（NSCLC）有不同的细胞遗传学畸变，但具有转移表型的NSCLC显示出与SCLC相同的畸变，SCLC是一种在发病时即以转移表型著称的肿瘤。纳入复发性染色体畸变模式的肺癌基因分类可能比形态学分类更能预测临床结果。
