髋部骨折恢复的一项性能指标产生了具有临床意义的差异。
A clinically meaningful difference was generated for a performance measure of recovery from hip fracture.
作者信息
Hawkes W G, Williams G R, Zimmerman S, Lapuerta P, Li T, Orwig D, Wehren L, Hebel J R, Magaziner J
机构信息
Division of Gerontology, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD 21201, USA.
出版信息
J Clin Epidemiol. 2004 Oct;57(10):1019-24. doi: 10.1016/j.jclinepi.2004.02.010.
BACKGROUND AND OBJECTIVE
The Lower Extremity Gain Scale (LEGS) is a performance measure of tasks that are often impaired in hip fracture patients. This study was designed to determine a clinically meaningful difference in LEGS.
METHODS
The population was 139 female patients (age >65 years) admitted to Baltimore hospitals. Recovery levels were estimated by fitting trajectory curves for the cohort for the 12 months post fracture. The clinically meaningful difference was evaluated using an anchor-based approach, examining the relationship between the LEGS recovery level and age. A second, distribution-based method used an effect size of .20.
RESULTS
According to our model, a difference of 5 years in age corresponded to a difference of 1.6-3.6 points in LEGS scores. The standard deviation for LEGS at 12 months was 8.0; thus, Cohen's effect size of 0.2 would equate to a difference of 1.6 points.
CONCLUSION
This suggests that a clinically meaningful difference in the LEGS scores for a population in this age range would be 2-3 points.
背景与目的
下肢功能改善量表（LEGS）是一种用于评估髋部骨折患者常受损任务的执行情况的工具。本研究旨在确定LEGS中具有临床意义的差异。
方法
研究对象为139名入住巴尔的摩医院的65岁以上女性患者。通过为骨折后12个月的队列拟合轨迹曲线来估计恢复水平。采用基于锚定的方法评估具有临床意义的差异，研究LEGS恢复水平与年龄之间的关系。第二种基于分布的方法使用的效应大小为0.20。
结果
根据我们的模型，年龄相差5岁对应于LEGS评分相差1.6 - 3.6分。12个月时LEGS的标准差为8.0；因此，科恩效应大小为0.2相当于相差1.6分。
结论
这表明在这个年龄范围内的人群中，LEGS评分具有临床意义的差异为2 - 3分。
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