Govoni S, Lucchi L, Battaini F, Trabucchi M
Pharmacobiology Dept., Univ. of Bari, Italy.
Life Sci. 1992;50(16):PL125-8. doi: 10.1016/0024-3205(92)90465-2.
Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glicerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.
在用两种认知增强剂奥拉西坦和α-甘油磷酸胆碱进行体内治疗后，测定了大鼠个体大脑皮层可溶性和颗粒性组分中的蛋白激酶C（PKC）活性。两种药物在治疗后1小时均诱导PKC颗粒活性增加（+40 - 50%）。这种作用是短暂的；在5小时时，PKC活性低于对照组。奥拉西坦的剂量反应曲线呈钟形，在100 mg/kg时PKC的增加具有显著性。在更高剂量时，该药物诱导酶活性降低。PKC活性增加可能与这些化合物的皮层效应有关。
