来自牙买加薇甘菊的米卡诺内酯。

Mikanolide from Jamaican Mikania micrantha.

作者信息

Bakir Mohammed, Facey Petrea C, Hassan Ishmael, Mulder Willem H, Porter Roy B

机构信息

Department of Chemistry, The University of the West Indies, Mona Campus, Kingston 7, Jamaica.

出版信息

Acta Crystallogr C. 2004 Nov;60(Pt 11):o798-800. doi: 10.1107/S0108270104017809. Epub 2004 Oct 9.

DOI:10.1107/S0108270104017809

PMID:15528823

Abstract

Mikanolide [systematic names: 1,10:2,3-diepoxy-6,8-dihydroxy-11-vinylgermacr-4-ene 12,14-di-gamma-lactone and 7,10a-dimethyl-1a,1b,2a,6a,7,9a,10,10a-octahydro-4H-6,3-methenofuro[3,2-c]bisoxireno[f,h]oxacycloundecin-4,8(6H)-dione], C(15)H(14)O(6), derived from a variety of Mikania micrantha growing in Portland, Jamaica, contains a methylcyclodecane ring fused to an unsaturated planar alpha,gamma-lactone, an envelope-type near-planar vinyl-beta,gamma-lactone and two epoxide moieties. The crystal packing shows stacks of mikanolide molecules interlocked via a network of non-classical C-H...O hydrogen bonds between the lactone units.

摘要

米卡诺内酯[系统命名：1,10:2,3-二环氧-6,8-二羟基-11-乙烯基吉马烯-4-烯12,14-二-γ-内酯和7,10a-二甲基-1a,1b,2a,6a,7,9a,10,10a-八氢-4H-6,3-亚甲基呋喃并[3,2-c]双环氧乙烷并[f,h]氧杂环十一烷-4,8(6H)-二酮]，化学式为C(15)H(14)O(6)，从牙买加波特兰生长的多种薇甘菊中提取，含有一个与不饱和平面α,γ-内酯稠合的甲基环癸烷环、一个信封型近平面乙烯基-β,γ-内酯和两个环氧基团。晶体堆积显示米卡诺内酯分子通过内酯单元之间的非经典C-H...O氢键网络相互锁定形成堆叠结构。