[一例经尸检的乳头状甲状腺癌显示DNA异质性——原发灶与转移灶之间DNA含量的比较]
[An autopsied case of papillary thyroid carcinoma showing DNA heterogeneity-comparison of DNA content between primary focus and metastatic focus].
作者信息
Komatsu M, Kobayashi S, Sugenoya A, Masuda H, Takahashi S, Iida F, Ito N
机构信息
Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
出版信息
Nihon Geka Gakkai Zasshi. 1992 Feb;93(2):208-11.
A 56-year-old female case of papillary thyroid carcinoma is reported. Nuclear DNA analysis using flow cytometry and immuno-histological staining with thyroglobulin, CA19-9 and CA125 of the primary and metastatic foci from the autopsy specimens were performed. Correlation between ploidy patterns and immuno-histological staining was not found. Although two histogram patterns namely DNA diploid (DP) and aneuploid (AP) with DNA index of 1.3 were seen in primary, sternal and lung metastatic foci, only DP pattern was seen in the lymph node metastatic foci.
报告了一例56岁女性甲状腺乳头状癌病例。对尸检标本的原发灶和转移灶进行了流式细胞术核DNA分析以及甲状腺球蛋白、CA19-9和CA125的免疫组织化学染色。未发现倍体模式与免疫组织化学染色之间的相关性。尽管在原发灶、胸骨转移灶和肺转移灶中观察到两种直方图模式，即DNA二倍体（DP）和DNA指数为1.3的非整倍体（AP），但在淋巴结转移灶中仅观察到DP模式。
Zotero 插件