Koh Chester J, Atala Anthony
Wake Forest Institute for Regenerative Medicine, Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Nephron Exp Nephrol. 2004;98(3):e65-70. doi: 10.1159/000080681.
Congenital abnormalities and acquired disorders can lead to organ damage or loss within the urinary tract. For reconstructive purposes, tissue engineering efforts are currently underway for virtually every type of tissue and organ within the urinary tract. Tissue engineering incorporates the fields of cell transplantation, materials science, and engineering for the purpose of creating functional replacement tissue, and requires personnel who have mastered the techniques of cell harvest, culture, expansion and transplantation, as well as polymer design. Major advances in the areas of stem cell biology, tissue engineering, and therapeutic cloning (nuclear transfer) techniques have made it possible to combine these technologies to create the comprehensive scientific field of regenerative medicine.
先天性异常和后天性疾病可导致尿路内的器官损伤或丧失。出于重建目的，目前正在对尿路内几乎每种类型的组织和器官进行组织工程研究。组织工程融合了细胞移植、材料科学和工程学领域，旨在创建功能性替代组织，并且需要掌握细胞采集、培养、扩增和移植技术以及聚合物设计的人员。干细胞生物学、组织工程和治疗性克隆（核移植）技术领域的重大进展使得将这些技术结合起来创建再生医学这一综合科学领域成为可能。
