Reich Olaf, Nogales Francisco F, Regauer Sigrid
Department of Obstetrics and Gynecology, Medical University of Graz, Austria.
Mod Pathol. 2005 Apr;18(4):573-6. doi: 10.1038/modpathol.3800325.
Gonadotropin-releasing hormone and its receptors have been identified in several human malignancies. We evaluated gonadotropin-releasing hormone receptor expression in 30 primary and recurrent endometrial stromal sarcomas. Archival formalin-fixed and paraffin-embedded material was analyzed immunohistochemically with antisera to gonadotropin-releasing hormone receptor type I and gonadotropin-releasing hormone receptor type II using the peroxidase-antiperoxidase method. Gonadotropin-releasing hormone receptor types I and II were demonstrated in most primary endometrial stromal sarcomas in varying intensity and percentage (range, 10-100%). The staining pattern was either diffuse cytoplasmic or granular/vesicular in perinuclear distribution. Recurrences stained stronger than primary tumors. The demonstration of gonadotropin-releasing hormone receptors I and II expression in endometrial stromal sarcomas may be a rationale for a clinical study of gonadotropin-releasing hormone analogs in the treatment of women with endometrial stromal sarcomas.
促性腺激素释放激素及其受体已在多种人类恶性肿瘤中被鉴定出来。我们评估了30例原发性和复发性子宫内膜间质肉瘤中促性腺激素释放激素受体的表达情况。采用过氧化物酶-抗过氧化物酶法，用抗I型促性腺激素释放激素受体和抗II型促性腺激素释放激素受体的抗血清对存档的福尔马林固定石蜡包埋材料进行免疫组织化学分析。I型和II型促性腺激素释放激素受体在大多数原发性子宫内膜间质肉瘤中均有不同强度和比例的表达（范围为10%-100%）。染色模式为弥漫性细胞质染色或核周分布的颗粒状/小泡状染色。复发病灶的染色比原发性肿瘤更强。子宫内膜间质肉瘤中I型和II型促性腺激素释放激素受体表达的证实可能为促性腺激素释放激素类似物治疗子宫内膜间质肉瘤女性的临床研究提供理论依据。
