Gundarova R A, Zueva M V, Tsapenko I V, Bykov V P, Velichko V A
Vestn Oftalmol. 2004 Sep-Oct;120(5):21-4.
Effects of blood serum from patients with endophthalmitis, who systematically received gentamicin at therapeutic dose, exerted on the retina of healthy rabbits were experimentally studied. A moderate toxic effect produced by gentamicin on the retina, when it was administered in the vitreous body of rabbits, was detected yet on day 1 of the experiment. Changes of retinal electrogenesis were aggravating and, beginning from day 7, there were noted profound changes of the functional activity in all retinal layers. According to the results, the blood serum from patients with endophthalmitis, who were systematically receiving gantamicin at therapeutic dose, does not virtually have any negative effect on the functional condition of the retina and can be used for intracavitary administration.
对系统性接受治疗剂量庆大霉素的眼内炎患者的血清对健康兔视网膜的影响进行了实验研究。当在兔玻璃体中给予庆大霉素时，在实验第1天就检测到其对视网膜产生中度毒性作用。视网膜电发生的变化不断加重，从第7天开始，所有视网膜层的功能活动都出现了深刻变化。结果表明，系统性接受治疗剂量庆大霉素的眼内炎患者的血清对视网膜的功能状况几乎没有任何负面影响，可用于腔内给药。
