Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based.

Searching for more efficient treatments for diabetic neuropathy continues to be a task for researchers and for practitioners also. The reasons are: the poor quality of life and the risk for ulcerations/amputations induced by peripheral diabetic neuropathy (PDP) (the most frequent manifestation of diabetic neuropathy) and the risk for sudden death and other manifestations attributed to autonomic neuropathy. There is a paucity of evidence based interventions for PDP. In this situation, the recent evidence (randomized, placebo controlled studies) regarding the efficacy of alpha-lipoic acid, a powerful antioxidant, are bringing new hopes.