Tripputi Pasquale, Bignotto Monica, Cigognini Daniela, Pellegrini Caterina, Corneo Gianmarco
Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi, Ospedale San Paolo di Milano.
Ann Ital Med Int. 2004 Jul-Sep;19(3):171-4.
B-chronic lymphocytic leukemia is a disease characterized by an accumulation of monoclonal B cells that are resistant to apoptosis. In chronic lymphocytic leukemia, the prognosis depends on the stage of the disease, according to the classifications of Rai and Binet. However, in recent years, the number of patients with very early disease (stage 0 of Rai) and without any clinical symptom, has considerably increased because of the extensive use of automatic apparatus for leukocyte counting and immunophenotypic analysis of lymphocytes. It has become, therefore, useful to find new prognostic criteria particularly for these patients. In the present study, 30 patients with B-chronic lymphocytic leukemia were investigated for stage of the disease, survival, immunoglobulin gene rearrangements, presence of nurse like cells in in vitro cultures and spontaneous clinical lymph node regression. We observed that all these criteria are useful prognostic indexes for the disease.
B 细胞慢性淋巴细胞白血病是一种以对凋亡有抗性的单克隆 B 细胞积聚为特征的疾病。在慢性淋巴细胞白血病中，根据 Rai 和 Binet 的分类，预后取决于疾病的阶段。然而，近年来，由于广泛使用自动白细胞计数仪和淋巴细胞免疫表型分析，极早期疾病（Rai 分期 0 期）且无任何临床症状的患者数量大幅增加。因此，找到新的预后标准，尤其是针对这些患者的标准变得很有用。在本研究中，对 30 例 B 细胞慢性淋巴细胞白血病患者进行了疾病分期、生存情况、免疫球蛋白基因重排、体外培养中是否存在类成纤维细胞以及临床淋巴结自发消退情况的研究。我们观察到所有这些标准都是该疾病有用的预后指标。
