Domercq María, Matute Carlos
Departamento de Neurociencias, Universidad del País Vasco, E-48940 Leioa, Vizcaya, Spain.
Trends Pharmacol Sci. 2004 Dec;25(12):609-12. doi: 10.1016/j.tips.2004.10.001.
The neuroprotective properties of tetracyclines have been clearly established in rodent models of acute and chronic neurodegeneration during the past few years. Recent findings have provided novel insights into the molecular and cellular mechanisms of protection of neurons and oligodendrocytes by tetracyclines. These advances have prompted several clinical trials with minocycline, the most effective tetracycline, which are still in their early phases. Thus, tetracyclines hold great promise as therapeutic agents for the treatment of human neurodegenerative diseases.
在过去几年中，四环素的神经保护特性已在急性和慢性神经退行性变的啮齿动物模型中得到明确证实。最近的研究结果为四环素对神经元和少突胶质细胞的保护作用的分子和细胞机制提供了新的见解。这些进展促使人们对最有效的四环素——米诺环素进行了几项仍处于早期阶段的临床试验。因此，四环素作为治疗人类神经退行性疾病的治疗药物具有很大的前景。
