老狗学新招：利用动物模型揭示细胞周期调节因子的意外作用。
New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models.
作者信息
Humbert Patrick O, Brumby Anthony M, Quinn Leonie M, Richardson Helena E
机构信息
Cell cycle and cancer genetics laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
出版信息
Curr Opin Cell Biol. 2004 Dec;16(6):614-22. doi: 10.1016/j.ceb.2004.09.001.
Studies in animal models have revealed many surprises regarding the importance of key cell cycle regulators during animal development and homeostasis, underscoring the plasticity and redundancy of cell cycle circuitry within a whole-animal context. Moreover, checkpoint regulators, which are not essential for viability in yeast and cultured cells, play important roles in cell cycle control during development.
对动物模型的研究揭示了许多关于关键细胞周期调节因子在动物发育和体内平衡中的重要性的惊人发现，突显了在整个动物背景下细胞周期调控网络的可塑性和冗余性。此外，在酵母和培养细胞中对生存力并非必需的检查点调节因子，在发育过程中的细胞周期控制中发挥着重要作用。
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