DNA损伤反应：感知与信号传导

The DNA damage response: sensing and signaling.

作者信息

McGowan Clare H, Russell Paul

机构信息

Department of Molecular Biology, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

Curr Opin Cell Biol. 2004 Dec;16(6):629-33. doi: 10.1016/j.ceb.2004.09.005.

DOI:10.1016/j.ceb.2004.09.005

PMID:15530773

Abstract

The protein kinases ATM and ATR are central components of the checkpoint mechanisms that signal the presence of damaged DNA and stalled replication forks. Recent studies have provided important new insights into how these kinases work together with their regulatory subunits, DNA repair proteins and adaptor proteins to sense abnormal DNA structures and implement the appropriate DNA damage response. These advances have provided a more detailed understanding of the interface between damaged DNA and the checkpoint sensor proteins.

摘要

蛋白激酶ATM和ATR是检查点机制的核心组成部分，这些机制可发出受损DNA和停滞复制叉存在的信号。最近的研究为这些激酶如何与其调节亚基、DNA修复蛋白和衔接蛋白协同工作以感知异常DNA结构并实施适当的DNA损伤反应提供了重要的新见解。这些进展使人们对受损DNA与检查点传感蛋白之间的界面有了更详细的了解。