Woodside J V, McMahon R, Gallagher A M, Cran G W, Boreham C A, Murray L J, Strain J J, McNulty H, Robson P J, Brown K S, Whitehead A S, Savage M, Young I S
School of Medicine, Queen's University, Mulhouse Building, Grosvenor Road, Belfast BT126BJ, Northern Ireland, UK.
Atherosclerosis. 2004 Dec;177(2):337-44. doi: 10.1016/j.atherosclerosis.2004.07.001.
Hyperhomocysteinaemia has been associated with reduced pulse wave velocity (PWV) in patients with end-stage renal disease and in those with hypertension. The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults.
A total of 489 subjects aged 20-25 years participated. A fasting blood sample was taken and PWV measured using a non-invasive optical method. tHcy did not correlate with PWV, whether assessed at the aorto-iliac segment (P = 0.18), the aorto-radial segment (P = 0.39) or the aorto-dorsalis-pedis segment (P = 0.22). When tHcy was classified into normal (<15) and high (> or =15micromol/l), PWV did not differ between the two groups at any segment. PWV did not differ by MTHFR C677T or NOS3 G894T genotype, even when smoking and folate sub-groups were considered. Considering aortic PWV as a dependent variable, stepwise regression analysis showed that the only parameter entering the model for all segments was systolic blood pressure (aorto-iliac, P < 0.001; aorto-radial, P = 0.01; aorto-dorsalis-pedis, P = 0.001). Age, sex, COL1A1 genotype and triglycerides entered the model significantly for two of three segments.
This study shows that arterial PWV is not associated with tHcy in a healthy young population.
高同型半胱氨酸血症与终末期肾病患者及高血压患者的脉搏波速度（PWV）降低有关。本研究的目的是探讨健康年轻成年人中总同型半胱氨酸（tHcy）浓度、tHcy的生化和遗传决定因素与PWV之间的关联。
共有489名年龄在20 - 25岁的受试者参与。采集空腹血样，采用非侵入性光学方法测量PWV。无论在主动脉 - 髂动脉段（P = 0.18）、主动脉 - 桡动脉段（P = 0.39）还是主动脉 - 足背动脉段（P = 0.22）进行评估，tHcy均与PWV无相关性。当将tHcy分为正常（<15）和高（≥15 μmol/l）时，两组在任何段的PWV均无差异。即使考虑吸烟和叶酸亚组，PWV在MTHFR C677T或NOS3 G894T基因型之间也无差异。以主动脉PWV作为因变量，逐步回归分析表明，所有段进入模型的唯一参数是收缩压（主动脉 - 髂动脉，P < 0.001；主动脉 - 桡动脉，P = 0.01；主动脉 - 足背动脉，P = 0.001）。年龄、性别、COL1A1基因型和甘油三酯在三个段中的两个段显著进入模型。
本研究表明，在健康年轻人群中，动脉PWV与tHcy无关。
