拉氏捕鸟蛛毒腺所表达毒素的分子克隆
Molecular cloning of toxins expressed by the venom gland of Lasiodora sp.
作者信息
Vieira A L G, Moura M B, Babá E H, Chávez-Olórtegui C, Kalapothakis E, Castro I M
机构信息
Laboratório de Biologia Celular e Molecular, Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus do Morro do Cruzeiro, Ouro Preto, MG 35.400-00, Brazil.
出版信息
Toxicon. 2004 Dec 15;44(8):949-52. doi: 10.1016/j.toxicon.2004.08.004.
The present work describes the identification of toxins expressed by the venom gland of the spider Lasiodora sp. The toxins LTx1, LTx2 and LTx3 were identified by the screening of a cDNA library. These toxins showed significant similarity at the amino acid level with spider toxins from Lasiodora parahybana, Eurypelma californicum, Brachypelma smithii, Selenocosmia huwena.
本研究描述了对蜘蛛Lasiodora sp.毒腺所表达毒素的鉴定。通过筛选cDNA文库鉴定出毒素LTx1、LTx2和LTx3。这些毒素在氨基酸水平上与来自巴西所罗门食鸟蛛、加州捕鸟蛛、墨西哥红膝头蛛、海南捕鸟蛛的蜘蛛毒素具有显著相似性。
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