中间美洲棕皮蝰（梅洛 - 莱唐）毒液中的洛克斯托克斯蛋白家族。
The Loxtox protein family in Loxosceles intermedia (Mello-Leitão) venom.
作者信息
Kalapothakis E, Chatzaki M, Gonçalves-Dornelas H, de Castro C S, Silvestre F G, Laborne F V, de Moura J F, Veiga S S, Chávez-Olórtegui C, Granier C, Barbaro K C
机构信息
Departamento de Biologia Geral Instituto de Ciências Biológicas; Universidade Federal de Minas Gerais, CEP 31270901 Belo Horizonte, MG, Brazil.
出版信息
Toxicon. 2007 Dec 1;50(7):938-46. doi: 10.1016/j.toxicon.2007.07.001. Epub 2007 Jul 27.
We isolated cDNA sequences coding for dermonecrotic/sphingomyelinases factor proteins from the brown spider Loxosceles intermedia, here named Loxtox proteins. The amino acid sequences based on cloned cDNA of several Loxtox proteins revealed at least six distinct groups of proteins expressed in the venom gland. The level of similarity among the toxins varied from 99% to 55%. The finding of several isoforms of Loxtox in the venom of this spider may reflect an evolutionary adaptation for different prey types and reinforces the idea of an efficient mutational mechanism in the venom gland of spiders.
我们从巴西游走蛛（Loxosceles intermedia）中分离出了编码皮肤坏死/鞘磷脂酶因子蛋白的cDNA序列，在此将其命名为Loxtox蛋白。基于几种Loxtox蛋白的克隆cDNA得出的氨基酸序列显示，毒腺中表达的蛋白至少有六个不同的组。这些毒素之间的相似性水平在99%至55%之间。在这种蜘蛛的毒液中发现多种Loxtox同工型，可能反映了对不同猎物类型的进化适应，并强化了蜘蛛毒腺中存在高效突变机制的观点。
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