Bailey R R, Lynn K L, Robson R A, Peddie B A, Smith A
Department of Nephrology, Christchurch Hospital.
N Z Med J. 1992 Mar 25;105(930):102-3.
A prospective, randomised trial was undertaken to compare the efficacy of ciprofloxacin and netilmicin for the treatment of acute pyelonephritis. Forty-three patients were enrolled and 34 (29 women) completed the protocol. Fifteen of 17 patients treated with ciprofloxacin and 15 of 17 treated with netilmicin were cured. All patients were treated for five days. One patient relapsed after ciprofloxacin and another had a reinfection, while two relapsed after netilmicin. Five of six patients with a urinary tract abnormality were cured. Side effects were generally mild and rapidly reversible. Patients treated with ciprofloxacin spent a mean of 3.7 days in hospital compared with 5.3 days for those treated with netilmicin. The difference in duration of hospital stay was statistically significant (p less than 0.01). Both drugs proved highly effective and safe for the treatment of severe acute pyelonephritis.
进行了一项前瞻性随机试验，比较环丙沙星和奈替米星治疗急性肾盂肾炎的疗效。43名患者入组，34名（29名女性）完成了方案。接受环丙沙星治疗的17名患者中有15名治愈，接受奈替米星治疗的17名患者中有15名治愈。所有患者均接受了5天的治疗。一名患者在使用环丙沙星后复发，另一名发生再感染，而两名患者在使用奈替米星后复发。6名有尿路异常的患者中有5名治愈。副作用一般较轻且可迅速逆转。接受环丙沙星治疗的患者平均住院3.7天，而接受奈替米星治疗的患者为5.3天。住院时间的差异具有统计学意义（p小于0.01）。两种药物在治疗严重急性肾盂肾炎方面均被证明高效且安全。
