Hur Sung Eun, Lee Ji Young, Moon Hye-Sung, Chung Hye Won
Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine and Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, South Korea.
Mol Hum Reprod. 2005 Jan;11(1):15-9. doi: 10.1093/molehr/gah127. Epub 2004 Nov 5.
Endometriosis, one of the most common gynaecologic disorders, shows significantly elevated prevalence in industrial areas and there is also a possible genetic predisposition. Glutathione-S-transferases (GSTs) are enzymes involved in the metabolism of many disease-causing carcinogens and mutagens that are present in human environments. An association between the incidence of endometriosis and the GST genotypes of patients has been suggested. The objective of the present study was to investigate whether the polymorphisms of GSTM1, GSTT1 and GSTP1 are related to endometriosis. Blood samples were available from 259 controls and 194 patients with advanced endometriosis diagnosed by both pathology and laparoscopic findings. The proportion of the GSTM1, GSTT1 and GSTP1 genotypes of the control group were comparable to other populations. There was no significant evidence that the distribution of the GSTM1 and GSTT1 genotype differed between the patients and the controls, with an allelic odds ratio (OR)=1.074 [95% confidence interval (CI)=0.737-1.564] and 1.239 (95% CI = 0.853-1.799), respectively. Also, there was no significant difference in the proportion of GSTP1 genotypes between the women with endometriosis and the control group with the OR = 0.823 (95% CI = 0.536-1.264). The higher risk alleles were contended as GSTM1, GSTT1 null mutation and GSTP1 Ile105Ile polymorphism. There was no significant increase in the risk of endometriosis as the number of higher risk alleles of the GST family increased. In conclusion, our findings suggest that the GSTM1, GSTT1 and GSTP1 genetic polymorphisms are not associated with the development of endometriosis in Korean women.
子宫内膜异位症是最常见的妇科疾病之一,在工业区的患病率显著升高,并且可能存在遗传易感性。谷胱甘肽 - S - 转移酶(GSTs)是参与许多人类环境中存在的致病致癌物和诱变剂代谢的酶。已有研究表明子宫内膜异位症的发病率与患者的GST基因型之间存在关联。本研究的目的是调查GSTM1、GSTT1和GSTP1的多态性是否与子宫内膜异位症有关。我们获取了259名对照者以及194名经病理和腹腔镜检查确诊为晚期子宫内膜异位症患者的血样。对照组中GSTM1、GSTT1和GSTP1基因型的比例与其他人群相当。没有显著证据表明患者和对照组之间GSTM1和GSTT1基因型的分布存在差异,其等位基因优势比(OR)分别为1.074 [95%置信区间(CI)= 0.737 - 1.564]和1.239(95% CI = 0.853 - 1.799)。此外,子宫内膜异位症女性与对照组之间GSTP1基因型的比例也没有显著差异,OR = 0.823(95% CI = 0.536 - 1.264)。较高风险的等位基因被认为是GSTM1、GSTT1无效突变和GSTP1 Ile105Ile多态性。随着GST家族高风险等位基因数量的增加,子宫内膜异位症的风险没有显著增加。总之,我们的研究结果表明,GSTM1、GSTT1和GSTP1基因多态性与韩国女性子宫内膜异位症的发生无关。