Lee Jun Ho, Ryu Keun Won, Kim Sung, Bae Jae Moon
Center for Gastric Cancer, Research Institute & Hospital, National Cancer Center, Goyang, Korea.
Hepatogastroenterology. 2004 Nov-Dec;51(60):1860-3.
BACKGROUND/AIMS: The aim of the present study was to investigate the relationship between the preoperative plasma fibrinogen level and the extent of tumor involvement in gastric cancer patients.
Preoperative plasma fibrinogen levels of 354 patients who underwent gastric cancer surgery were quantified using an immunoassay. The relationships between the plasma fibrinogen level and other prognostic variables (tumor size, macroscopic and histological type, depth of tumor invasion, presence of lymph node involvement and distant metastasis) were then examined using univariate and multivariate linear regression analyses.
The plasma fibrinogen level was significantly lower in patients with early gastric cancer than in those with advanced gastric cancer (312+/-6.7 vs. 361.9+/-97.0 mg/mL, p<0.001). A significant relationship existed between the preoperative fibrinogen levels and the presence of metastatic lymph nodes (320+/-78.6 vs. 352.6+/-94.1 mg/mL, p=0.001) and distant metastasis (338.2+/-89.5 vs. 396.9+/-128.3 mg/mL, p=0.013). Size of the tumors and depth of tumor invasion could predict elevated fibrinogen levels positively in both the univariate regression and multivariate linear regression analyses.
These data suggest that the plasma fibrinogen level is a clinically important and useful marker of the extent of tumor progression in gastric cancer.
背景/目的:本研究旨在探讨胃癌患者术前血浆纤维蛋白原水平与肿瘤累及范围之间的关系。
采用免疫分析法对354例行胃癌手术患者的术前血浆纤维蛋白原水平进行定量分析。然后,使用单因素和多因素线性回归分析研究血浆纤维蛋白原水平与其他预后变量(肿瘤大小、大体和组织学类型、肿瘤浸润深度、淋巴结受累情况和远处转移)之间的关系。
早期胃癌患者的血浆纤维蛋白原水平显著低于进展期胃癌患者(312±6.7 vs. 361.9±97.0 mg/mL,p<0.001)。术前纤维蛋白原水平与转移性淋巴结的存在(320±78.6 vs. 352.6±94.1 mg/mL,p=0.001)和远处转移(338.2±89.5 vs. 396.9±128.3 mg/mL,p=0.013)之间存在显著关系。在单因素回归和多因素线性回归分析中,肿瘤大小和肿瘤浸润深度均可正向预测纤维蛋白原水平升高。
这些数据表明,血浆纤维蛋白原水平是胃癌肿瘤进展程度的一个重要临床有用标志物。