Kilic M, Yoldas O, Keskek M, Ertan T, Tez M, Gocmen E, Koc M
V Department of Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Colorectal Dis. 2008 Mar;10(3):238-41. doi: 10.1111/j.1463-1318.2007.01374.x. Epub 2007 Sep 13.
Plasma D-dimer levels have been shown to be increased in patients with various solid tumours including lung, prostate, cervical, ovarian, breast and colon cancer. The purpose of this prospective study was to estimate the plasma D-dimer level of patients with colorectal cancer before surgery and to assess whether it has a prognostic value.
The study comprised 51 patients with colorectal cancer. Variables including demographic, clinical, operative and pathological findings and routine laboratory tests were recorded. In addition, tumour markers, coagulation tests and plasma D-dimer levels were evaluated.
Histological types other than well-differentiated adenocarcinoma, relatively advanced tumour stage and a high preoperative plasma D-dimer level were the prognostic factors that were associated with shorter postoperative survival according to univariate analyses. The presence of vascular invasion was associated with higher preoperative D-dimer levels. However, there was no statistically significant relationship between postoperative survival and the presence of vascular invasion.
Postoperative survival was significantly shorter in colorectal cancer patients with elevated preoperative D-dimer levels. Evaluation of preoperative D-dimer level can be used to predict postoperative survival.
血浆D - 二聚体水平在包括肺癌、前列腺癌、宫颈癌、卵巢癌、乳腺癌和结肠癌在内的各种实体瘤患者中已显示升高。这项前瞻性研究的目的是估计结直肠癌患者术前的血浆D - 二聚体水平，并评估其是否具有预后价值。
该研究包括51例结直肠癌患者。记录了包括人口统计学、临床、手术和病理结果以及常规实验室检查等变量。此外，还评估了肿瘤标志物、凝血试验和血浆D - 二聚体水平。
根据单因素分析，高分化腺癌以外的组织学类型、相对晚期的肿瘤分期和术前血浆D - 二聚体水平高是与术后生存期较短相关的预后因素。血管侵犯的存在与术前较高的D - 二聚体水平相关。然而，术后生存期与血管侵犯的存在之间没有统计学上的显著关系。
术前D - 二聚体水平升高的结直肠癌患者术后生存期明显较短。术前D - 二聚体水平的评估可用于预测术后生存期。
