Leifsson P S, Agerholm J S
Department of Veterinary Pathobiology, Bülowsvej 17, 1870 Frederiksberg C, Denmark.
J Vet Med A Physiol Pathol Clin Med. 2004 Sep-Oct;51(7-8):332-5. doi: 10.1111/j.1439-0442.2004.00652.x.
Bovine dilated cardiomyopathy (BDCM) is a hereditary disease genetically related to the Canadian Holstein sire Montwick Red Apple Sovereign (MRAS). The occurrence of this disorder in the Red Danish Dairy breed, Holsteins, and Red Holsteins in Denmark is reported. Fourteen cases were diagnosed during a 13-year period. All suffered from congestive heart failure because of progressive myocardial fibrosis. Pedigree information was available in 12 cases revealing both maternal and paternal relationship to MRAS. Several sires were identified as carriers of BDCM. These sires originated from breeding lines used to upgrade Danish cattle populations. The findings indicate that BDCM is a potential health problem for Danish cattle.
牛扩张型心肌病（BDCM）是一种与加拿大荷斯坦种公牛蒙特维克红苹果君主（MRAS）存在遗传关联的遗传性疾病。本文报道了这种疾病在丹麦红丹麦奶牛品种、荷斯坦奶牛以及红荷斯坦奶牛中的发生情况。在13年的时间里共诊断出14例病例。所有病例均因进行性心肌纤维化而患有充血性心力衰竭。12例病例有系谱信息，显示其与MRAS存在母系和父系关系。有几头种公牛被确定为BDCM携带者。这些种公牛来自用于改良丹麦牛群的育种系。研究结果表明，BDCM对丹麦牛来说是一个潜在的健康问题。
