Nix P A, Greenman J, Cawkwell L, Stafford N D
Postgraduate Medical Institute of the University of Hull, in association with the Hull York Medical School, Hull, UK.
Clin Otolaryngol Allied Sci. 2004 Dec;29(6):705-8. doi: 10.1111/j.1365-2273.2004.00861.x.
Survival rates for head and neck cancer are comparatively poor, typically 40% at 5 years. Radiotherapy is one of the most common modalities used to cure early-stage cancers. It has the advantage in that it preserves anatomical structure and function. However, treatment failures do occur necessitating salvage surgery if a cure is to be achieved. A universally accepted definition of radioresistant cancer does not exist. Second primaries and occult metastasis are common in head and neck cancer, and can be confused with true radioresistant tumours. We suggest a strict definition for radioresistant laryngeal cancer and characterize 66 radioresistant tumours stage matched to 66 radiosensitive tumours. It was not possible to differentiate the radioresistant group from the radiosensitive groups using tumour differentiation. By using an agreed set of criteria defining radioresistant head and neck tumours, researchers will be better able to investigate molecular and cellular markers of radioresistance.
头颈癌的生存率相对较低，5年生存率通常为40%。放射治疗是治疗早期癌症最常用的方法之一。其优势在于能保留解剖结构和功能。然而，治疗失败确实会发生，如果要实现治愈就需要进行挽救性手术。目前尚无关于放射抗拒性癌症的普遍接受的定义。第二原发癌和隐匿性转移在头颈癌中很常见，可能会与真正的放射抗拒性肿瘤相混淆。我们提出了放射抗拒性喉癌的严格定义，并对66例放射抗拒性肿瘤进行了特征描述，这些肿瘤与66例放射敏感性肿瘤进行了分期匹配。使用肿瘤分化无法将放射抗拒组与放射敏感组区分开来。通过使用一套商定的定义放射抗拒性头颈肿瘤的标准，研究人员将能够更好地研究放射抗拒性的分子和细胞标志物。
