5-羟色胺2A受体基因的T102C多态性可能与颞下颌关节紊乱症相关。
T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction.
作者信息
Mutlu N, Erdal M E, Herken H, Oz G, Bayazit Y A
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Selcuk University, Konya, Turkey.
出版信息
Oral Dis. 2004 Nov;10(6):349-52. doi: 10.1111/j.1601-0825.2004.01037.x.
OBJECTIVE
To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction.
METHODS
Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique.
RESULTS
The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05).
CONCLUSION
The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level.
目的
评估5-羟色胺2A受体基因T102C多态性与颞下颌关节紊乱病之间是否存在关联。
方法
本研究纳入63例颞下颌关节紊乱病患者和54名健康志愿者作为对照。采用聚合酶链反应（PCR）技术对5-羟色胺2A受体基因T102C多态性进行分子分析。
结果
患者中C/C基因型占比过高，而对照组中T/T基因型占比过高（P < 0.05）。患有颞下颌关节紊乱病的患者与未患颞下颌关节紊乱病的患者的基因型分布无差异（P > 0.05）。
结论
T102C多态性可能参与颞下颌关节紊乱病的病因。5-羟色胺2A受体基因C/C变异体在颞下颌关节紊乱病中占比过高，提示5-羟色胺能系统在该疾病中可能发挥作用，尤其是在受体水平。
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