5-羟色胺2A受体基因多态性与首发（未用药）汉族精神分裂症患者的阴性症状
5-HT2A receptor gene polymorphism and negative symptoms in first episode (drug-naive) Chinese Han nationality individuals with schizophrenia.
作者信息
Wang Yu-hong, Li Wen-qiang, Huang Zhao, Shi Yu-zhong, Wang Xu-Yi, Huang Jin-song, Zhou Xu-hui, Chen Hong-xian, Hao Wei
机构信息
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Apr;33(4):293-8.
OBJECTIVE
To investigate whether the 5-hydroxytryptamine 2A receptor (5-HT2A) gene T102C polymorphism is associated with the severity symptoms and negative symptoms in the first episode Chinese Han nationality patients with schizophrenia.
METHODS
Altogether 201 first episode Chinese Han nationality patients with schizophrenia were enrolled in this study. Genotyping of 5-HT2A gene T102C polymorphism was performed by PCR-RFLP technique. The positive and negative Symptom Scale (PANSS) was used for the evaluation of the severity of psychotic symptoms before any drug treatment.
RESULTS
5-HT2A receptor 102-T/T genotype was significantly associated with both the PANSS total and negative symptom subscale baseline scores before the treatment, but not with the positive and general psychopathology subscales.
CONCLUSION
5-HT2A T102C functional polymorphism may play a role in negative symptoms and prognosis of Chinese Han nationality people with schizophrenia.
目的
探讨5-羟色胺2A受体（5-HT2A）基因T102C多态性与首发汉族精神分裂症患者的严重症状及阴性症状是否相关。
方法
本研究共纳入201例首发汉族精神分裂症患者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对5-HT2A基因T102C多态性进行基因分型。在任何药物治疗前，使用阳性和阴性症状量表（PANSS）评估精神病性症状的严重程度。
结果
5-HT2A受体102-T/T基因型与治疗前PANSS总分及阴性症状分量表基线评分显著相关，但与阳性症状和一般精神病理分量表无关。
结论
5-HT2A T102C功能多态性可能在汉族精神分裂症患者的阴性症状及预后中起作用。
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