Healy Eugene
Dermatology, University of Southampton, UK.
Photodermatol Photoimmunol Photomed. 2004 Dec;20(6):283-8. doi: 10.1111/j.1600-0781.2004.00132.x.
The melanocortin 1 receptor is a key regulator of variation in normal human pigmentation. Genetic variants of this receptor cause red hair and fair skin, and several case-control studies have demonstrated that these genetic variants increase the risk of skin cancer development in humans. The mechanism whereby the risks of skin cancer are increased is not entirely clear, and may be because of a combination of effects on pigmentation and non-pigmentary pathways.
黑皮质素1受体是人类正常色素沉着变异的关键调节因子。该受体的基因变异会导致红头发和白皙皮肤，多项病例对照研究表明，这些基因变异会增加人类患皮肤癌的风险。皮肤癌风险增加的机制尚不完全清楚，可能是对色素沉着和非色素途径的综合影响所致。
