McKenna K E
Department of Dermatology, Belfast City Hospital, Belfast, UK. kevin.mckenna@@bch.n-i.nhs.uk
Photodermatol Photoimmunol Photomed. 2004 Dec;20(6):289-96. doi: 10.1111/j.1600-0781.2004.00123.x.
Photochemotherapy (psoralen/UVA (PUVA)) is an efficient therapeutic tool for a wide range of skin diseases. Concern, however, exists regarding the long-term carcinogenic effects of this treatment modality and, as a consequence, is being used less frequently. PUVA remains an important treatment in our therapeutic armamentarium but must be used with caution in those patients with risk factors and cumulative dose exposure must be limited. PUVA-induced cancers show features in common with skin cancers induced by immunosuppressed organ transplant recipients. Tumours in the latter group of individuals are, however, much more aggressive and difficult to manage.
光化学疗法（补骨脂素/紫外线A（PUVA））是治疗多种皮肤病的有效手段。然而，人们担心这种治疗方式的长期致癌作用，因此其使用频率正逐渐降低。PUVA仍是我们治疗手段中的重要方法，但对于有风险因素的患者必须谨慎使用，且累积剂量暴露必须加以限制。PUVA诱发的癌症与免疫抑制器官移植受者诱发的皮肤癌有共同特征。然而，后一组个体的肿瘤更具侵袭性且更难治疗。
