Bruce Deborah, Robinson Jillian, McWilliams Sarah, Reddy Mamatha, Fentiman Ian, Rymer Janice
Menopause Research Unit, Guy's Hospital, London, United Kingdom.
Fertil Steril. 2004 Nov;82(5):1343-7. doi: 10.1016/j.fertnstert.2004.03.063.
To investigate the long-term effect of tibolone on mammographic density.
Open-label, nonrandomized study.
Academic research environment.
PATIENT(S): Postmenopausal women.
INTERVENTION(S): Tibolone was administered orally, mammograms were performed annually.
MAIN OUTCOME MEASURE(S): Mammographic density according to the Wolfe classification, performed by two independent radiologists, both of whom were blinded to treatment group.
RESULT(S): No statistically significant differences were found between the two groups in baseline demographic data. There were no statistically significant differences in mammographic density between the control and active groups at baseline or at 10 years.
CONCLUSION(S): This pilot study shows that tibolone does not adversely alter the mammographic density of the breasts over 10 years of treatment.
研究替勃龙对乳房X线密度的长期影响。
开放标签、非随机研究。
学术研究环境。
绝经后女性。
口服替勃龙，每年进行乳房X线摄影。
根据沃尔夫分类法得出的乳房X线密度，由两名独立的放射科医生进行评估，他们均对治疗组情况不知情。
两组在基线人口统计学数据方面未发现有统计学意义的差异。在基线时或10年后，对照组和治疗组之间的乳房X线密度无统计学意义的差异。
这项初步研究表明，在10年的治疗期间，替勃龙不会对乳房的X线密度产生不利影响。
