Ho C, Hwang G C
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Northeastern University, Boston, Massachusetts 02115.
Pharm Res. 1992 Feb;9(2):206-10. doi: 10.1023/a:1018933306162.
Extended-release solid dispersions of nonsteroidal antiinflammatory drugs were prepared by using aqueous polymeric dispersions of Eudragit RS30D and Eudragit RL30D as the inert carriers. The effects of different polymer ratios of Eudragit RS30D and Eudragit RL30D, different particle sizes, and different combination of various formulations of solid dispersions on the in vitro release kinetics of drugs from the dosage forms were investigated. A computer curve-fitting process was developed to choose the optimum formulation of the solid dispersion with the desired drug release profile. This process might offer the advantages of efficiency and simplicity in the formulation development of extended-release solid dispersions.
以Eudragit RS30D和Eudragit RL30D的水性聚合物分散体为惰性载体，制备了非甾体抗炎药的缓释固体分散体。研究了Eudragit RS30D和Eudragit RL30D不同聚合物比例、不同粒径以及各种固体分散体配方的不同组合对剂型药物体外释放动力学的影响。开发了一种计算机曲线拟合程序，以选择具有所需药物释放曲线的固体分散体的最佳配方。该程序可能在缓释固体分散体的制剂开发中提供效率和简便性方面的优势。
