Eskandari H Gulcin, Cimen M Y Burak, Tamer Lulufer, Kanik Arzu, Atik Ugur
Medical Faculty, Department of Biochemistry and Biostatistics, Mersin University, Tip Fak. Hastanesi, Biyokimya AD., Zeytinlibahce Cad., 33079 Mersin, Turkey.
Diabetes Res Clin Pract. 2004 Nov;66(2):129-32. doi: 10.1016/j.diabres.2004.03.005.
The aim of this study was to evaluate the effects of L-carnitine supplementation on serum triglyceride and total cholesterol levels in streptozotocin (STZ)-induced diabetic rats. Thirty-two male Wistar rats were divided into diabetic and diabetic-L-carnitine-supplemented groups. Diabetes was induced by injection of a single dose of streptozotocin (40 mg/kg, intraperitoneally) in citrate buffer. L-Carnitine was supplemented by IM injection of 100 mg/kg per day for 10 days. Serum glucose, triglyceride and total cholesterol levels were determined at days 0, 5 and 10. Rats receiving L-carnitine had lower triglyceride levels at both days 5 and 10 (P < 0.05). Total cholesterol levels in the carnitine-supplemented group were lower, but statistical significance was achieved only at day 10 (P < 0.05). These results suggest that L-carnitine exhibits hypotriglyceridemic and hypocholesterolemic effects in streptozotocin-induced diabetic rats. Clinical trials of L-carnitine supplementation on patients with diabetes induced hyperlipidemia must be further evaluated.
本研究的目的是评估补充左旋肉碱对链脲佐菌素（STZ）诱导的糖尿病大鼠血清甘油三酯和总胆固醇水平的影响。32只雄性Wistar大鼠被分为糖尿病组和补充左旋肉碱的糖尿病组。通过在柠檬酸盐缓冲液中腹腔注射单剂量链脲佐菌素（40mg/kg）诱导糖尿病。通过每天肌肉注射100mg/kg的左旋肉碱，持续10天进行补充。在第0、5和10天测定血清葡萄糖、甘油三酯和总胆固醇水平。接受左旋肉碱的大鼠在第5天和第10天的甘油三酯水平均较低（P<0.05）。补充肉碱组的总胆固醇水平较低，但仅在第10天达到统计学显著性（P<0.05）。这些结果表明，左旋肉碱对链脲佐菌素诱导的糖尿病大鼠具有降甘油三酯和降胆固醇作用。必须进一步评估补充左旋肉碱对糖尿病诱导的高脂血症患者的临床试验。
