Samuelsson U, Sadauskaite V, Padaiga Z, Ludvigsson J
Division of Paediatrics, Department of Health and Environment, Linköping University, Linköping S-581 85, Sweden.
Diabetes Res Clin Pract. 2004 Nov;66(2):173-81. doi: 10.1016/j.diabres.2004.03.001.
We investigated whether other autoimmune disorders in addition to type 1 diabetes are more common in Sweden than Lithuania, and if there are any differences in inheritance patterns of both type 1 diabetes and other autoimmune disorders. Data from 517 children in southeast Sweden and 286 children in Lithuania aged 0-15 years were included in the study. Age- and sex-matched control children were randomly selected. Information was collected by questionnaire. Of the children with diabetes in Sweden, 13.2% had a family member with type 1 diabetes compared to 7% of children with diabetes in Lithuania (P < 0.01) (OR = 2.01). No such difference was seen for other autoimmune diseases in family members of children with diabetes (Sweden 12%, Lithuania 14%, n.s.). Control children in Lithuania had family members with autoimmunity more frequently (15.3%) than control children in Sweden (7.4%, P < 0.001) (OR = 2.26). This difference was most pronounced in mothers. The Lithuanian control children had an autoimmune disease more frequently than the controls in Sweden (4.7% versus 1.5%, respectively, P < 0.001) (OR = 3.21). There seem to be environmental factors that specifically contribute to the development of type 1 diabetes, factors which are less related to the development of autoimmunity in general.
我们调查了除1型糖尿病外的其他自身免疫性疾病在瑞典是否比立陶宛更常见，以及1型糖尿病和其他自身免疫性疾病的遗传模式是否存在差异。该研究纳入了瑞典东南部517名0至15岁儿童以及立陶宛286名0至15岁儿童的数据。随机选取年龄和性别匹配的对照儿童。通过问卷调查收集信息。在瑞典患有糖尿病的儿童中，13.2%有家庭成员患1型糖尿病，而立陶宛患有糖尿病的儿童这一比例为7%（P < 0.01）（OR = 2.01）。糖尿病儿童家庭成员中其他自身免疫性疾病未见此类差异（瑞典12%，立陶宛14%，无统计学意义）。立陶宛的对照儿童有自身免疫性疾病家庭成员的比例（15.3%）高于瑞典的对照儿童（7.4%，P < 0.001）（OR = 2.26）。这种差异在母亲中最为明显。立陶宛的对照儿童患自身免疫性疾病的比例高于瑞典的对照儿童（分别为4.7%和1.5%，P < 0.001）（OR = 3.21）。似乎存在一些特定的环境因素促成1型糖尿病的发生，而这些因素与一般自身免疫性疾病的发生关系较小。
