Pallàs M, Verdaguer E, Jordà E G, Jiménez A, Canudas A M, Camins A
Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, E-08028 Barcelona, Spain.
Med Hypotheses. 2005;64(1):120-3. doi: 10.1016/j.mehy.2004.03.047.
Several lines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and amyotrophic lateral sclerosis. Given their role in the neuronal apoptosis, the inhibition of CDKs by specific drugs such as flavopiridol may be a valid therapeutic approach. Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans.
多项证据表明，细胞周期蛋白依赖性激酶（CDK）与神经退行性疾病有关，如阿尔茨海默病、帕金森病和肌萎缩侧索硬化症。鉴于它们在神经元凋亡中的作用，用诸如黄酮哌啶醇等特定药物抑制CDK可能是一种有效的治疗方法。在兴奋性毒性和中风的啮齿动物模型中观察到了CDK的表达，并且CDK抑制剂显示出神经保护作用。黄酮哌啶醇可能会显著改善人类的神经退行性疾病。
