Schmidt H H, Renner H, Linkesch W
Department of Internal Medicine, Division of Hematology, University Medical School of Graz, Austria.
Haematologica. 2004 Nov;89(11):ECR39.
A patient with CD20(+) leukaemic lymphoplasmacytic Non-Hodgkin's lymphoma (NHL) presented with bilateral malignant pleural effusions. Systemic chemotherapy, repeated percutaneous drainage and bilateral continous chest tube drainage were unable to control the effusions. Rituximab was instilled in a dose-escalating manner via the chest tubes into both pleural spaces, within two weeks the effusions resolved, and the patient has stayed free of symptoms for eight months ongoing. Rituximab may be a promising novel treatment option for malignant effusions in CD20(+) NHL.
一名患有CD20(+)白血病性淋巴浆细胞性非霍奇金淋巴瘤（NHL）的患者出现双侧恶性胸腔积液。全身化疗、反复经皮引流和双侧持续胸腔闭式引流均无法控制积液。通过胸腔引流管以剂量递增的方式向双侧胸腔内注入利妥昔单抗，两周内积液消退，患者至今已无症状8个月。利妥昔单抗可能是治疗CD20(+) NHL恶性积液的一种有前景的新选择。
