Thompson Mary F, Scott-Moncrieff J Catharine, Brooks Marjory B
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.
J Am Anim Hosp Assoc. 2004 Nov-Dec;40(6):446-54. doi: 10.5326/0400446.
Thirteen dogs with primary immune-mediated hemolytic anemia received fresh-frozen plasma within 12 hours of admission, in addition to unfractionated heparin and other therapies, such as prednisone, azathioprine, and packed red blood cell transfusion. Antithrombin activity was quantified prior to transfusion and at 30 minutes and 48 hours after transfusion. Plasma antithrombin activity did not change significantly after a single plasma transfusion. There were no deaths in the first 48 hours of treatment. Thromboembolism was identified at necropsy in six of 10 dogs that died within 12 months of admission. There was no significant difference in the incidence of thromboembolism between the current treatment group and a historical control group.
13只患有原发性免疫介导性溶血性贫血的犬在入院12小时内接受了新鲜冷冻血浆治疗，此外还接受了普通肝素及其他治疗，如泼尼松、硫唑嘌呤和浓缩红细胞输血。在输血前、输血后30分钟和48小时对抗凝血酶活性进行了定量。单次输血后血浆抗凝血酶活性无显著变化。治疗的前48小时内无死亡病例。在入院后12个月内死亡的10只犬中，有6只在尸检时发现有血栓栓塞。当前治疗组与历史对照组之间血栓栓塞的发生率无显著差异。
