Krüger S, Stanzel F, Morresi-Hauf A, Häussinger K
Asklepios Fachkliniken, Zentrum für Pneumologie und Thoraxchirurgie, München-Gauting.
Pneumologie. 2004 Nov;58(11):769-72. doi: 10.1055/s-2004-830041.
Endobronchial lipoma is a very rare benign lung tumor. Therapeutic alternatives are the interventional bronchoscopic laser resection or surgical treatment.
From 1996 to 2002 we diagnosed 16 patients with endobronchial lipoma in our institution. We examined the clinical data of the patients and their influence on the individual patient treatment.
14 (88 %) out of the 16 patients (60 +/- 14 y.) were male. Clinical symptoms were cough (81 %), dyspnea (75 %), pulmonary infiltration (63 %) and fever (31 %). In the right lung 11 lipomas (69 %) were located, in the left lung 5 lipomas (31 %). The distribution to main bronchus, upper lobe, middle lobe and lower lobe bronchus were 2 (12.5 %), 6 (37.5 %), 2 (12.5 %) und 6 (37.5 %). 14 (88 %) lipomas were found in the central airways, 2 were located in the periphery of the lung. All lipomas in the central airways were successfully treated by bronchoscopic laser therapy with a mean of 1.1 +/- 0.3 laser sessions. One patient died of concomitant bronchial carcinoma before therapy. Surgical treatment was only necessary in a very peripherally located huge lipoma and a lipoma with extensive parenchym destruction.
Bronchoscopic laser resection should be considered as first line therapy in cases of endobronchial lipoma. It is safe, successful, rapid and less expensive compared to surgical resection. Surgery should only be indicated in patients with lipomas with very peripherally localisation or parenchym destruction, extrabronchial growth, suspected malignancy or technical problems at bronchoscopic resection.
支气管内脂肪瘤是一种非常罕见的良性肺肿瘤。治疗方法有介入性支气管镜激光切除术或手术治疗。
1996年至2002年,我们机构诊断出16例支气管内脂肪瘤患者。我们检查了患者的临床资料及其对个体患者治疗的影响。
16例患者(60±14岁)中有14例(88%)为男性。临床症状有咳嗽(81%)、呼吸困难(75%)、肺部浸润(63%)和发热(31%)。11例脂肪瘤(69%)位于右肺,5例脂肪瘤(31%)位于左肺。在主支气管、上叶、中叶和下叶支气管的分布分别为2例(12.5%)、6例(37.5%)、2例(12.5%)和6例(37.5%)。14例(88%)脂肪瘤位于中央气道,2例位于肺周边。中央气道内的所有脂肪瘤均通过支气管镜激光治疗成功治愈,平均激光治疗次数为1.1±0.3次。1例患者在治疗前死于合并的支气管癌。仅在非常周边部位的巨大脂肪瘤和有广泛实质破坏的脂肪瘤患者中需要进行手术治疗。
对于支气管内脂肪瘤病例,应将支气管镜激光切除术视为一线治疗方法。与手术切除相比,它安全、成功、快速且成本较低。仅在脂肪瘤位于非常周边部位或有实质破坏、支气管外生长、怀疑恶性或支气管镜切除存在技术问题的患者中才应考虑手术治疗。