质谱在生物标志物/分子示踪剂解析中的当前应用综述。
A review of current applications of mass spectrometry for biomarker/molecular tracer elucidation.
作者信息
Simoneit Bernd R T
机构信息
Environmental and Petroleum Research Group, College of Oceanic and Atmospheric Sciences and Department of Chemistry, Oregon State University, Corvallis, Oregon 97331-5503, USA.
出版信息
Mass Spectrom Rev. 2005 Sep-Oct;24(5):719-65. doi: 10.1002/mas.20036.
Mass spectrometry, especially coupled with gas chromatography or tandem, is the analytical method of choice in elucidation of biomarker compounds present in organic mixtures extracted from geological, environmental, or biological samples. This review describes the biomarker concept; i.e., the precursor natural products to the geological/environmental derivatives, and their application as tracers in the geosphere and ambient environment. The mass spectrometric methods currently utilized for such analyses are reviewed, and typical examples of applications are described with a general key to the literature.
质谱分析法，尤其是与气相色谱联用或串联质谱分析法，是用于阐明从地质、环境或生物样品中提取的有机混合物中存在的生物标志物化合物的首选分析方法。本综述描述了生物标志物的概念，即地质/环境衍生物的前体天然产物，及其作为地球圈层和周围环境中示踪剂的应用。本文综述了目前用于此类分析的质谱方法，并通过文献通用索引描述了典型的应用实例。
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