Sterlinko Grm Helena, Banks Lawrence
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Antivir Ther. 2004 Oct;9(5):665-78.
Human papillomaviruses (HPV) are the aetiological agents of several types of anogenital tumours, particularly cervical carcinoma. Recent evidence also suggests a role for HPV in the development of squamous cell carcinomas of the skin, especially in immunocompromised individuals. HPV infection also produces a number of non-malignant, but nonetheless cosmetically unpleasant lesions. Therefore, any effective therapeutic treatment for HPV-induced diseases would be extremely beneficial both on humanitarian grounds as well as being economically very attractive. In this review, we will discuss the functions of the viral proteins that appear to be the most appropriate for the development of therapeutics aimed at the treatment of viral infection and virus-induced cancers.
人乳头瘤病毒（HPV）是多种肛门生殖器肿瘤的病原体，尤其是宫颈癌。最近的证据还表明HPV在皮肤鳞状细胞癌的发生发展中起作用，特别是在免疫功能低下的个体中。HPV感染还会产生一些非恶性但在外观上令人不悦的病变。因此，任何针对HPV引起的疾病的有效治疗方法，无论从人道主义角度还是经济角度来看都将极具益处。在这篇综述中，我们将讨论病毒蛋白的功能，这些功能似乎最适合开发针对病毒感染和病毒诱导癌症的治疗方法。
