Cui Hu-jun, Xin Wei-qiang, Tan Yan-fen
Department of Cardiac Surgery, First Hospital, Peking University, Beijing 100034, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Nov;16(11):673-6.
To analyze the clinical significance of the prognosis assessment with acute physiology and chronic health evaluation III (APACHEIII), multiple organ dysfunction score (MODS) and sequential organ failure assessment (SOFA) for postoperative patients in cardiovascular surgery.
Prognosis of 68 patients undergoing cardiovascular operation from February 2004 to June 2004 in our ward was assessed by APACHE III, MODS and SOFA. Then the scores were calculated and compared everyday while they stayed in Cardiac Surgery Intensive Care Unit (CSICU).
The scores of three methods showed no significant difference from one another in the first three postoperative days, but were significantly higher than all the scores calculated just after the entrance to the CSICU (A0, M0, S0; all P<0.01). There were no differences in the changes of APACHE III, MODS and SOFA(DeltaA, DeltaM and DeltaS) in the first three postoperative days respectively, although they all showed a decreasing tendency. APACHE III scores were positively correlated with MODS although the correlation were diminishing (P<0.01 at first day but P<0.05 at third day), while they were positively correlated with SOFA only in the first two days (both P<0.01). The MODS was positively correlated with SOFA at various time points (P<0.001). The length of stay in CSICU was positive correlated with A0 and maximum of APACHEIII (Amax, P<0.05), and M0, maximum of MODS (Mmax) as well as S0, maximum of SOFA (Smax, P<0.001), respectively.
For the patients who have undergone cardiovascular operation, A0 could assess the prognosis fairly precisely, but MODS and SOFA assessment seem to be better than APACHE III. Individual Smax and kinetic DeltaS might be the most suitable indexes for cardiovascular surgery.
分析急性生理学与慢性健康状况评分系统III(APACHEIII)、多器官功能障碍评分(MODS)及序贯器官衰竭评估(SOFA)对心血管外科术后患者预后评估的临床意义。
对2004年2月至2004年6月在我科接受心血管手术的68例患者,采用APACHE III、MODS和SOFA进行预后评估。在他们入住心脏外科重症监护病房(CSICU)期间,每天计算并比较评分。
术后前3天,三种方法的评分彼此间无显著差异,但均显著高于刚进入CSICU时计算的所有评分(A0、M0、S0;均P<0.01)。术后前3天,APACHE III、MODS和SOFA(ΔA、ΔM和ΔS)的变化虽均呈下降趋势,但彼此间无差异。APACHE III评分与MODS呈正相关,尽管相关性逐渐减弱(第1天P<0.01,第3天P<0.05),而仅在前2天与SOFA呈正相关(均P<0.01)。MODS在各时间点与SOFA呈正相关(P<0.001)。CSICU住院时间分别与A0和APACHEIII最大值(Amax,P<0.05)、M0和MODS最大值(Mmax)以及S0和SOFA最大值(Smax,P<0.001)呈正相关。
对于接受心血管手术的患者,A0能较准确地评估预后,但MODS和SOFA评估似乎优于APACHE III。个体Smax和动态ΔS可能是心血管手术最合适的指标。