Stahl John S
Department of Neurology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Vision Res. 2004 Dec;44(28):3401-10. doi: 10.1016/j.visres.2004.09.011.
Examining eye movements is an important part of the neurological evaluation of humans; the distribution of the neural circuits that control these movements is such that they are disrupted--often in highly characteristic fashions--by many disease processes. Technical advances have made it possible to measure accurately the eye movements of mice, so it is now possible to use the detective power of eye movement recording to characterize neurological dysfunction in genetically altered strains. Here we introduce analytical tools used in ocular motor research and demonstrate their ability to reveal disorders of the visual pathways, inner ear, and cerebellum.
检查眼球运动是对人类进行神经学评估的重要部分；控制这些运动的神经回路分布使得它们在许多疾病过程中常常以高度特征性的方式受到破坏。技术进步使得准确测量小鼠的眼球运动成为可能，因此现在可以利用眼球运动记录的检测能力来表征基因改变品系中的神经功能障碍。在这里，我们介绍了用于眼球运动研究的分析工具，并展示了它们揭示视觉通路、内耳和小脑疾病的能力。
