Ramsey Susan E, Kahler Christopher W, Read Jennifer P, Stuart Gregory L, Brown Richard A
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island 02903, USA.
J Stud Alcohol. 2004 Sep;65(5):672-6. doi: 10.15288/jsa.2004.65.672.
The purpose of this study is to examine the accuracy with which the depressive episodes of alcoholics undergoing treatment are classified as substance-induced depression (SID) or independent major depressive disorder (MDD).
Participants were 95 patients (64 men) undergoing partial hospital treatment for alcohol dependence. Affective disorders were assessed at baseline and 6 weeks, 3 months, 6 months and 12 months later.
Over one quarter of the depressive episodes originally diagnosed as SID were reclassified as MDD during the 1-year follow-up, due to a continuation of the depressive episode despite a period of prolonged abstinence from alcohol and drugs. Both history of MDD and lower levels of alcohol dependence were associated with diagnostic change from SID to MDD.
These findings support the diagnostic complexity of these two types of depressive disorders and point to clinical features that may differentiate them.
本研究旨在检验接受治疗的酗酒者的抑郁发作被分类为物质所致抑郁（SID）或独立的重度抑郁障碍（MDD）的准确性。
参与者为95名因酒精依赖接受部分住院治疗的患者（64名男性）。在基线时以及6周、3个月、6个月和12个月后对情感障碍进行评估。
在1年的随访期间，超过四分之一最初被诊断为SID的抑郁发作被重新分类为MDD，原因是尽管有一段时间长期戒酒和戒毒，但抑郁发作仍持续存在。MDD病史和较低的酒精依赖水平都与从SID到MDD的诊断变化有关。
这些发现支持了这两种类型抑郁障碍的诊断复杂性，并指出了可能区分它们的临床特征。
