Prøven A
Oslo Sanitetsforenings Revmatismesykehus, Oslo.
Tidsskr Nor Laegeforen. 1992 Feb 10;112(4):479-82.
Mixed connective tissue disease can be regarded as a distinct rheumatic disease syndrome. It can be differentiated from the other systemic rheumatic diseases and overlap syndromes, and has its own diagnostic criteria. The article presents symptoms, treatment, outcome, classification and diagnosis of mixed connective tissue disease. The most usual symptoms are Raynaud's phenomenon, swelling of the hands, polyarthritis, muscle weakness, oesophageal hypomotility and pulmonary disease. The recommended therapy should be based on patterns of involvement of organ systems and the severity of the disease. In severe cases the treatment is often a combination of corticosteroids and cytostatics. Due to severe impacts on lungs and kidneys it seems necessary to modify earlier predictions of a generally favourable outcome in patients with mixed connective tissue disease.
混合性结缔组织病可被视为一种独特的风湿性疾病综合征。它可与其他系统性风湿性疾病及重叠综合征相鉴别，并有其自身的诊断标准。本文介绍了混合性结缔组织病的症状、治疗、预后、分类及诊断。最常见的症状有雷诺现象、手部肿胀、多关节炎、肌肉无力、食管动力不足及肺部疾病。推荐的治疗应基于器官系统受累模式及疾病严重程度。在严重病例中，治疗通常是皮质类固醇和细胞抑制剂联合使用。由于对肺和肾有严重影响，似乎有必要修正之前对混合性结缔组织病患者总体预后良好的预测。
