Bargagli Elena, Bigliazzi Caterina, Leonini Alessandra, Nikiforakis Nikolaos, Perari Maria G, Rottoli Paola
Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, Le Scotte Hospital, 53100 Siena, Italy.
Clin Sci (Lond). 2005 Mar;108(3):273-6. doi: 10.1042/CS20040178.
In order to characterize BAL (bronchoalveolar lavage) in CEP (chronic eosinophilic pneumonia) and to investigate the possible role of mast cells and tryptase in the pathogenesis of this interstitial disease, cells and tryptase levels were determined in BAL of patients with CEP and in a group of healthy controls. The results show that a statistically significant increase in tryptase concentration was found in patients with CEP compared with the healthy controls. This is the first report that shows an increase in tryptase levels in CEP and could reflect higher mast cell activation as well as larger mast cell populations in the lungs of these patients. These results strongly support the involvement of mast cells and eosinophils in the immunopathogenesis of CEP.
为了明确慢性嗜酸性粒细胞性肺炎（CEP）中支气管肺泡灌洗（BAL）的特征，并研究肥大细胞和类胰蛋白酶在这种间质性疾病发病机制中的可能作用，我们测定了CEP患者BAL中的细胞和类胰蛋白酶水平，并与一组健康对照进行比较。结果显示，与健康对照相比，CEP患者的类胰蛋白酶浓度有统计学意义的显著升高。这是首份显示CEP中类胰蛋白酶水平升高的报告，可能反映了这些患者肺内肥大细胞的更高活化程度以及更大的肥大细胞数量。这些结果有力地支持了肥大细胞和嗜酸性粒细胞参与CEP免疫发病机制的观点。
