Morrow P E
Department of Biophysics, University of Rochester.
Toxicol Appl Pharmacol. 1992 Mar;113(1):1-12. doi: 10.1016/0041-008x(92)90002-a.
This article reviews recent studies which involve, or impact on, the condition of dust overloading in the lungs of several species, especially the Fischer 344 rat. Its main purpose is to provide an update of the overload concept and new information of possible mechanistic relevance. At present, the most likely general explanation for the suppression of particle transport by the alveolar macrophage (AM) and the development of concurrent events, e.g., increased interstitial dust uptake and prolonged inflammatory response, is the persistent, possibly excessive, elaboration of chemotactic and chemokinetic factors by the AM. The induction of these interrelated events is hypothesized as related to the volume of dust phagocytized by the AM pool. The review concludes, inter alia, that information is badly needed on dust overload in nonrodent species and on the normal role of the AM in dust removal from the human lungs.
本文回顾了近期涉及或影响多种物种肺部粉尘超载情况的研究，特别是费希尔344大鼠。其主要目的是更新超载概念，并提供可能具有机制相关性的新信息。目前，对于肺泡巨噬细胞（AM）抑制颗粒运输以及并发事件（如间质粉尘摄取增加和炎症反应延长）的发生，最可能的一般性解释是AM持续产生，可能是过度产生趋化因子和化学动力学因子。这些相互关联事件的诱导被假定与AM池吞噬的粉尘量有关。该综述特别指出，非常需要有关非啮齿动物物种粉尘超载以及AM在人类肺部清除粉尘中的正常作用的信息。
