用于小动物成像的高分辨率正电子发射断层扫描仪定量能力评估。

Evaluation of the quantitative capability of a high-resolution positron emission tomography scanner for small animal imaging.

作者信息

Fahey Frederic H, Gage H Donald, Buchheimer Nancy, Smith Holly C, Harkness Beth A, Williams Rodney C, Bounds Michael C, Mercier Jennifer, Robbins Michael E C, Payne R Mark, Morton Kathryn A, Mach Robert H

机构信息

Division of Nuclear Medicine, Children's Hospital, Boston, MA 02115, USA.

出版信息

J Comput Assist Tomogr. 2004 Nov-Dec;28(6):842-8. doi: 10.1097/00004728-200411000-00020.

DOI:10.1097/00004728-200411000-00020

PMID:15538162

Abstract

OBJECTIVE

The quantitative capability of a positron emission tomography scanner for small animal imaging was evaluated in this study.

METHODS

The microPET P4 (Concorde Microsystems, Knoxville, TN) scanner's capability for dynamic imaging and corrections for radioactive decay, dead time, and attenuation were evaluated. Rat brain and heart studies with and without attenuation correction were compared. A calibration approach to convert the data to nanocuries per milliliter was implemented. Calibration factors were determined using calibration phantoms of 2 sizes with and without attenuation correction. Quantitation was validated using the MiniPhantom (Data Spectrum, Chapel Hill, NC) with hot features (5:1 ratio) of different sizes (4, 6.4, 8, 13, and 16 mm).

RESULTS

The microPET P4 scanner's ability to acquire dynamic studies and to correct for decay, dead time, and attenuation was demonstrated. The microPET P4 scanner provided accurate quantitation to within 6% for features larger than 10 mm. Sixty percent of object contrast was retained for features as small as 4 mm.

CONCLUSIONS

The microPET P4 scanner can provide accurate quantitation.

摘要

目的

本研究评估了一台用于小动物成像的正电子发射断层扫描仪的定量能力。

方法

对microPET P4（康科德微系统公司，田纳西州诺克斯维尔）扫描仪的动态成像能力以及放射性衰变、死时间和衰减校正进行了评估。比较了大鼠脑部和心脏在有和没有衰减校正情况下的研究。实施了一种将数据转换为每毫升纳居里的校准方法。使用有和没有衰减校正的两种尺寸的校准体模确定校准因子。使用具有不同尺寸（4、6.4、8、13和16毫米）热特征（5:1比例）的MiniPhantom（数据光谱公司，北卡罗来纳州教堂山）验证定量。