Klausner Adam P, Steers William D
Department of Urology, University of Virginia Health System, Charlottesville, Virginia, USA.
J Urol. 2004 Dec;172(6 Pt 2):2570-3. doi: 10.1097/01.ju.0000144142.26242.f3.
We review evidence linking overactive bladder (OAB) and interstitial cystitis with anxiety and depression, and highlight the importance of corticotropin releasing factor (CRF) as a potential mediator of these conditions.
We review the literature and describe ongoing experiments.
CRF is expressed in areas of the central nervous system that control voiding and response to stress. CRF is increased during anxiety, depression and pain as well as functional disorders of the pelvic viscera. Epidemiological studies reveal an association between anxiety and voiding disorders. Experiments in our laboratory show that CRF stimulates bladder activity while CRF antagonists inhibit OAB.
Epidemiological, genetic and neuropharmacological evidence links disorders of voiding and anxiety. CRF may participate in these events and warrants further investigation as a therapeutic target in the treatment of OAB and interstitial cystitis.
我们回顾了将膀胱过度活动症（OAB）和间质性膀胱炎与焦虑和抑郁联系起来的证据，并强调促肾上腺皮质激素释放因子（CRF）作为这些病症潜在介质的重要性。
我们回顾了文献并描述了正在进行的实验。
CRF在控制排尿和应激反应的中枢神经系统区域表达。在焦虑、抑郁、疼痛以及盆腔脏器功能障碍期间，CRF会增加。流行病学研究揭示了焦虑与排尿障碍之间的关联。我们实验室的实验表明，CRF刺激膀胱活动，而CRF拮抗剂抑制膀胱过度活动症。
流行病学、遗传学和神经药理学证据将排尿障碍与焦虑联系起来。CRF可能参与了这些事件，作为膀胱过度活动症和间质性膀胱炎治疗的治疗靶点值得进一步研究。
